The above picture, A, reveals collagen deposition (fluorescent inexperienced) in tendon tissue after stimulation by hyaluronic acid. Picture B reveals virtually no collagen when hyaluronic acid is just not added. (From Oliva 2021 by way of Artistic Commons License.)
Many individuals are conversant in hyaluronic acid (HA) as a topical agent, utilized by many women to enhance pores and skin hydration and easy wrinkles, given HA’s skill to bind appreciable portions of water molecules. HA can also be injected into joints to extend joint lubrication (knees, hips, shoulders), into pores and skin as a brief filler to cut back wrinkles, administered into the colon by way of enema to cut back the irritation of ulcerative colitis, and utilized topically within the vagina as a lubricant. However the true energy of hyaluronic acid comes with oral ingestion, simply because it was alleged to happen if we added again misplaced dietary sources.
Organ meats, particularly mind, kidney, coronary heart, intestines, and pores and skin, are wealthy in HA. The fashionable aversion to organ meats has due to this fact precipitated a widespread lack of HA consumption that, I consider, is inflicting accelerated growing older of pores and skin, joints, and different organs, maybe together with the mind. Lack of HA compromises the intestinal barrier to microbial byproducts and permits better intestinal and body-wide irritation.
HA content material of organs drops as we age. Age-related discount is particularly marked in pores and skin, with older folks having as much as 90% much less dermal HA in comparison with younger folks. HA is plentiful in joints, discovered each in cartilage and within the joint lubricant, additionally diminished in amount as we age. HA can also be present in beneficiant portions in human breast milk, essential for gastrointestinal maturation of the breastfeeding toddler (and yet one more deficiency of artificial toddler formulation).
It’s clear that orally-ingested HA makes its option to the dermal layer of pores and skin, the joint lubricating fluid in knees, hips and different joints, tendons and ligaments, the eyes, and different organs. After ingestion, HA is metabolized by intestine microbes into smaller fragments which can be absorbed and distributed all through the physique. Because the photograph above demonstrates, HA stimulates collagen deposition (as does collagen supplementation, additionally).
HA additionally has prebiotic properties and has been proven to markedly improve the inhabitants of Akkermansia muciniphila, the keystone species that exerts quite a few useful metabolic results together with diminished insulin resistance, diminished blood sugar, and elevated manufacturing of intestinal mucus. One other keystone species, Faecalibacterium prausnitzii, produces elevated portions of useful fatty acids resembling butyrate when “fed” HA. Utilized orally, HA additionally reduces oral pathogens.
HA ingestion due to this fact might be anticipated to:
- Improve pores and skin moisture and cut back wrinkle depth
- Improve joint lubrication (glycosaminoglycan and proteoglycans) and cut back arthritis ache
By the best way, if the proof demonstrating that HA, particularly when mixed with collagen hydrolysates additionally absent from the trendy eating regimen, reduces arthritis ache, will increase joint lubrication, and might improve cartilage quantity, why are medical doctors so eager on injecting HA instantly into joints, however not on oral supplementation? Ah, effectively, you may cost cash for injections, however not for advocating an oral complement.
- Yield metabolic well being enhancements—not less than partly because of the prebiotic fiber properties of HA
- Cut back intestinal irritation by growing the intestinal immune response
- Cut back penetrability of the gastrointestinal lining (thereby possible lowering endotoxemia and body-wide irritation)
- Improved wound therapeutic
Per the consumption of one thing that ought to be a pure element of eating regimen, no adversarial results of HA have ever been reported throughout dozens of human medical trials.
You’ll be able to certainly acquire HA by bringing organ meats again into your eating regimen. Most trendy folks, nevertheless, discover this objectionable. On the very least, you can improve HA consumption by consuming the pores and skin on poultry (NEVER boneless, skinless rooster breast, the epitome of low-fat blunders!) and fish, eat sausages encased in pure casings, make soups from the carcass of animals you’ve consumed, however the whole amount ingested shall be modest. Supplementation can due to this fact be the answer.
If we had been to eat the mind of an animal, we might acquire round 7.4 grams of HA from a 4-ounce serving. A variety of HA doses have been explored however usually 40-240 mg per day. However is that the perfect consumption? That is an unanswered query, however can be price exploring. As a result of HA is so water-absorbent, small portions generate substantial hydrating results.
Picture supply: Oliva F, Marsilio E, Asparago G, Frizziero A, Berardi AC, Maffulli N. The Influence of Hyaluronic Acid on Tendon Physiology and Its Medical Software in Tendinopathies. Cells. 2021 Nov 9;10(11):3081.