Wednesday, September 14, 2022
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Have We Found the Fountain of Youth?

Fountain of youth

These of you following my weblog, in addition to its predecessor, the Wheat Stomach Weblog, know that I’m an enormous fan of the microbe, Lactobacillus reuteri, L. reuteri.

Recall that L. reuteri is ubiquitous in human populations unexposed to antibiotics and different microbiome-disruptive components distinctive to trendy life. If we have been to due to this fact analyze the intestinal microbiome of native New Guineans who spear or membership their subsequent meal, dig within the dust for roots and tubers, collect berries, birds, eggs, mushrooms, drink from rivers and puddles, haven’t any operating water, and so forth. all of them have L. reuteri. If we have been to evaluate the intestinal microbiomes of wolves, squirrels, rabbits, or deer within the forest, who likewise devour meals foraged from the wild, all of them have L. reuteri. Sequence the intestinal microbiome of a contemporary American, nonetheless, and you might be unlikely to search out L. reuteri—practically all of us have misplaced this microbe. The German microbiologist, Dr. Gerhard Reuter, who first recognized this microbe in human breast milk in 1962, discovered it more and more troublesome to isolate this species from people over his subsequent 40-year profession. That is seemingly due to the microbe’s susceptibility to widespread antibiotics comparable to penicillin, amoxicillin, and others.

A wealth of experimental proof, in addition to a rising variety of human medical trials, recommend that almost all results of L. reuteri are as a consequence of elevated launch of oxytocin from the hypothalamus and pituitary glands within the mind, thereby making it a prototypical “psychobiotic.” Restoration of this misplaced microbe, L. reuteri, has been related to:

  • Restoration or preservation of youthful muscle and power—Recall that we sometimes lose about 35% of muscle mass as we age. Whereas it might enhance power in youthful folks, this remark suggests L. reuteri yields a youth-preserving impact in opposition to age-related muscle loss, together with sarcopenia within the aged frail.
  • Preservation of bone densityCurrent proof suggests that there’s half as a lot bone loss with restoration of L. reuteri in comparison with placebo. That is additionally per observations made in experimental research (e.g., elevated osteoblast exercise in constructing the weather of bone).
  • Upkeep of sexual conduct—Animals expertise this as mating and grooming whilst outdated mice. People expertise this as upkeep of sexual curiosity and libido as we age.
  • Restoration of youthful immunity—Two research now doc that age-related lack of T-cell immunity as a consequence of atrophy of the thymus gland reverses with L. reuteri. This might doubtlessly imply that age-related lack of immunity and immunosurveillance (in opposition to look of most cancers cells) could also be addressed or reversed with restoration of this microbe.
  • Deeper, extra sustained sleep—With (actigraphically-measured) extension of REM (fast eye-movement) durations. This remark is anecdotal, not but formally studied. I personally expertise it to an extravagant diploma, changing me from a persistent insomniac to somebody who enjoys deep, uninterrupted sleep each evening.
  • Acceleration of therapeutic—Pores and skin wounds inflicted on animals and people heal extra quickly, interpreted to be a gauge of youthful therapeutic responses that stretch past pores and skin.
  • Discount in endotoxemia—This impact has far-reaching potential implications together with reductions in insulin resistance, blood sugar, blood stress, and different measures. That is seemingly a consequence of L. reuteri’s upper-GI colonizing capacity and its capability to provide bacteriocins, pure antibiotics efficient in opposition to lots of the species of small intestinal bacterial overgrowth, SIBO, that I consider is epidemic within the U.S.
  • Improve in empathy, social connection, and accepting the opinions of others—These are the results that I discover essentially the most attention-grabbing. It makes you a greater member of a group, higher capable of perceive and join with different folks.

Stronger muscular tissues and bones, heightened immunity, deeper sleep, accelerated therapeutic, lowered irritation. I hope that you’re starting to understand the large implications for human well being—emotional, bodily, and social–of restoring this misplaced microbe. I don’t suppose it’s a stretch to say that L. reuteri and its increase in oxytocin make you a greater human being. It’s not about longevity; it’s about sustaining youthfulness and vigor for so long as potential. However it’s a microbe misplaced by the vast majority of folks. Restoring it, I consider, is a genuinely large benefit for the human expertise. Restoration of L. reuteri gained’t make a 70-year outdated right into a 20-year outdated, however I consider it turns again the clock on lots of the phenomena of ageing by 10-20 years. I don’t know of the rest that has this impact but is so benign, so accessible, and accompanied by so many different useful results.



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